Former criminals and failed heroes work one by one for Valentina Allegra De Fontaine, head of the CIA. Valentina sends Elena Belova, John Walker, Ava Starr, and Antonia Dreikova on missions to cover up illegal human experimentation. One day Valentina sends them all to one secret facility to prevent the theft of classified data. The four operatives meet and realize that they were ordered to kill each other because they were the last witnesses to Valentina's crimes.