Kadie has spent her entire life in Kenya with her zoologist mom and homeschooled, so when she finds herself in an ordinary American high school, everything seems new and strange to her. Suddenly she's invited into her company by the school's most popular girl, Regina George, and new pals Janice and Damian are incited to agree in order to spy on the local queen and her minions. But when Cady falls in love with Regina's ex-boyfriend, the former "friends" become bitter rivals.